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Target Validation Shared Resource

Summary:

The Target Validation Shared Resource (TVSR) assists investigators in generating reliable proof-of-concept preclinical animal model data for grant applications, publications and IND applications for the FDA.

Preclinical mouse models of cancer have become indispensable for in vivo target validation studies, such as determining in vivo efficacy of therapeutics, unraveling in vivo off-target effects of therapeutics including unexpected negative side-effects in a whole organism, elucidating significance of biological pathways towards disease initiation/progression etc. The Target Validation Shared Resource assists investigators with these in vivo target validation studies.

The TVSR shared resource has expertise in establishing breeding programs for GEMM (genetically engineered mouse model) animals and immune-compromised mouse strains, developing xenograft/allograft mouse models of cancer, therapeutic compound administration and subsequent monitoring of the animals. It also provides consultation towards in vivo target validation study design.

The goal of TVSR is to assist investigators in generating reliable “proof-of-concept” preclinical animal (mouse) model data for grant applications, publications and filing of IND applications to FDA.

Affiliations:

People:

    Resources:

    Resource Collection

    • The Ohio State University Comprehensive Cancer Center Collection ( Resource Collection )

      The OSUCCC – James Shared Resources and core facilities provide specialized services to cancer researchers. They offer cost-effective, state-of-the-art technology and instrumentation; expert guidance and training; and clinical, administrative and technical support.

    Services


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    Last updated: 2020-12-16T11:01:44.791-05:00

    Copyright © 2016 by the President and Fellows of Harvard College
    The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016