The approach taken by OSU Center for Pharmacogenomics (C-PGx) spans across basic biomedical sciences and functional genomics to clinical implementation. In addition, the C-PGx educates academic and industrial scientists, health-care professionals, and the public, about the potential of pharmacogenomics in medical practice. The C-PGx focuses on the discovery of genetic variants that serve as biomarkers guiding successful drug therapy in individual patients. C-PGx has developed new approaches for the discovery of genetic variants, with focus on gene regulation, including innovative genome-scale technologies such as massively-parallel sequencing and data integration. Together with numerous collaborators across the world, C-PGx scientists have already generated clinically relevant biomarkers guiding optimal therapies for the individual patient.