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Core Laboratories at The Ohio State University

This is a summary list of all core laboratories at The Ohio State University . The list includes links to more detailed information, which may also be found using the eagle-i search app.

CCTS Biostatistics, Epidemiology, and Research Design

Summary:

Collaboration with a biostatistician typically provides higher quality and reliable results that stand up to critical peer review. Issues that are not obvious to investigators are identified and addressed and all efforts are made to ensure the investigator’s aims are met through statistically rigorous methods.

Biostatisticians vary in their area of expertise. Some focus on clinical trial design, analysis and oversight, others focus on observational study methods, laboratory experimental design and analysis, or high dimensional studies (microarray, sequence data, etc.). Specific biostatistical expertise is also important to peer reviewers.



CCTS Community Engagement

Summary:

• Educational Opportunities to help research team members learn the most effective ways to identify, engage with, and incorporate valuable feedback from their stakeholders.
• Connect and Engage with collaborative research partners across OSU and NCH, and with local, regional, and statewide community partners and organizations (including Central Ohio, Southeastern Ohio/Appalachia, and OSU Extension offices across the state).
• Cultural Competency and Dissemination opportunities to connect with stakeholders via Science Cafés & Community Advisory Boards.
• Community Scientist Academy provides an opportunity for community stakeholders to learn more about translational research and the various ways they can get involved via a six-week program (meets once per week)
• Consultation and Feedback from CE Program staff and our Community Advisory Boards (Faculty, Central Ohio, and Southeast Ohio/Appalachia)
• CE Pilot grants through the CE Program’s partnership with the CCTS Pilot and
Collaborative Studies Program
• Appalachian Translational Research Network (ATRN) provides a network of academic research institutions designed to establish partnerships and connect with communities and organizations in the Appalachian Region



CCTS Comparative and Translational Medicine

Summary:

Comparative and Translational Medicine

The goal of the Comparative and Translational Medicine (CTM) program is to leverage natural diseases in animals to create an integrated platform for collaborative research, therapeutic interrogation, cross discipline training and outreach across OSU, NCH and its partners. The program supports interactive, multi-disciplinary research via several initiatives. With the overriding goal of advancing the diagnosis and treatment of diseases in veterinary patients while enhancing the health of humans through comparative and translational studies.

CTM initiatives include:

Nodes of Comparative Medicine
The nodes of comparative medicine consist of organized teams of researchers and clinicians focusing on specific health areas of high translational potential. Node leaders work to connect researchers and veterinary clinician-scientists to facilitate veterinary clinical trials on the translational spectrum.
• Infectious Disease (Michael Oglesbee/Oglesbee.1@osu.edu)
• Comparative Oncology (Joelle Fenger/Fenger.3@osu.edu)
• Renal Disease and Pathology (Rachel Cianciolo/Cianciolo.14@osu.edu)
• Neuromusculoskeletal Disease (Sarah Moore/Moore.2204@osu.edu)

Translational Therapeutics Think Tank (T4)
The mission of the Translational Therapeutics Think Tank (T4) is to provide consultation and guidance for investigators working in novel drug/device discovery and development within the OSU and NCH communities. Investigators can request a meeting with a panel of content experts customized to their specific research-related questions by visiting go.osu.edu/ccts-t4.

The Blue Buffalo Veterinary Clinical Trials Office and the Biospecimen Repository
The BBVCTO has a mission to advance the diagnosis and treatment of disease in veterinary patients through interdisciplinary collaborative research efforts within the CVM, OSU and NCH communities while improving the health of humans through comparative research efforts.

The BBVCTO is available to:

• Assist with protocol development
• Interface with industry sponsors
• Confirm compliance with appropriate approvals
• Formulate and review study budgets
• Conduct studies according to GCP guidelines
• Generate CRF’s and data capture/REDCap
• QA/QC Data
• Recruit patients through various marketing tools
• Oversee and assist with clinical trial performance
• Provide study financial management
• Collect, process, and store study samples
• Biospecimen sample requests are available at: eramp.osumc.edu



CCTS Informatics

Summary:

Research Informatics is a group of highly trained software engineers, IT professionals, and biomedical informatics technicians that is a part of the Department of Biomedical Informatics (BMI). This team leverages the skills and tools that exist within OSU’s Department of BMI and OSUWMC’s Information Technology Department (OSUWMC-IT) in order to provide an informatics-based catalyst in support of novel, multi-disciplinary clinical and translational science endeavors.



CCTS Integrating Special Populations

Summary:

The ISP program offers free consultations on inclusivity in research program design to NCH/OSU faculty investigators and study teams interested in integrating special populations in research, as well as pilot funding to support research initiatives involving groups that are frequently underrepresented in clinical and translational research. The ISP pilot program supports new applications annually and focuses on research programs aimed at the study of a special population or who are seeking to enhance an existing program to be more accessible to diverse participants.



CCTS Nationwide Children's Drug and Device Development Services

Summary:

Assistance for medical faculty and investigators from pre-clinical to clinical trials, as well as guidance for external partners and collaborators through the regulatory landscape.



CCTS Nationwide Children's Hospital Biobehavioral Outcomes Core

Summary:

Services include consultation in design of research with behavioral components; selection of behavioral measurement techniques and instruments; assistance in behavioral outcomes sections of grant applications and manuscripts; and assistance with collection, scoring, and analysis of behavioral data; and assistance with qualitative methods.



CCTS Nationwide Children's Hospital Biopathology Center

Summary:

Services include biospecimen processing, banking, distribution, and virtual microscopy.



CCTS Nationwide Children's Hospital Clinical Research Services

Summary:

Streamlined coordination of services necessary to initiate clinical research projects, regardless of funding source, as well as provision of staff and/or services to manage studies according to Good Clinical Practice and federal, state, and institutional regulations and guidelines.



CCTS Nationwide Children's Hospital Intramural funding

Summary:

IMF grants are available to physicians, psychologists and other clinical staff at with an OSU faculty appointment, as well as residents and fellows. Research Institute faculty are eligible if collaborating with an NCH clinician. Fellows can apply for up to $10,000 and faculty can request up to $50,000. There are 3 application cycles annually, with special RFAs announced to target areas of interest.



CCTS Nationwide Children's Hospital Research Information Solutions and Innovation

Summary:

IT assistance to researchers on data processing from acquisition, curating and management to analysis and visualization, including both clinical and non-clinical basic research data.



CCTS Participant Clinical Interactions

Summary:

The Participant and Clinical Interactions (PCI) Program provides administrative support for investigator-initiated multicenter clinical research trials. The PCI Program is tasked with providing facilities and resources to investigators conducting human subjects research at OSU and NCH.

PCI connects investigators to local established clinical and translational research entities, leveraging collective resources and expertise of:
• OSU College of Medicine Clinical Trials Management Organization (CTMO)
• OSU Comprehensive Cancer Center Clinical Trials Office (CTO)
• OSU Clinical Research Center (CRC)
• NCH Clinical Research

PCORI and NIH proposal development services are provided through the CCTS PCI program formulticenter clinical research trials for:
• Study budgets
• Project management plans
• Leadership / Organizational plans
• Securing letters of support



CCTS Pilot Funding

Summary:

The purpose of the Pilot Translational & Clinical Studies (PTC) Program of the OSU CCTS is to fund meritorious pilot projects by cross-disciplinary teams from The Ohio State University and Nationwide Children’s Hospital to generate preliminary data and refine research strategies for subsequent extramural grant applications or towards commercialization. The mission of CCTS Pilot Programs (PTC) is to catalyze innovation, translational science, team science and workforce development by funding or co-sponsoring projects. This is done through interdisciplinary teams with patient and community engagement to develop novel methods, tools, therapies, technologies and policies. The PTC program employs innovative funding mechanisms and programming dedicated to enhancing the quality and efficiency of translational endeavors.



CCTS Recruitment and Retention

Summary:

Recruitment and Retention can help design those first touch points with the community and share best practices to help researchers achieve their recruitment/retention goals. The goal of every research study is one that is fully recruited with high retention. In order to make that goal a possibility, research teams are encouraged to request recruitment/retention consultation early in the planning and design stages of their studies to reduce the burden of study participant recruitment, which can often be more challenging than expected.



CCTS Regulatory Knowledge and Support

Summary:

Navigating the federal and local regulatory landscape can be time consuming and confusing. The goal of the regulatory knowledge and support services is to advise research studies in navigating the requirements for federal and local regulations. In order to make that goal a possibility, research teams are encouraged to request regulatory consultation early in the planning and design stages of their studies.
The CCTS Regulatory Knowledge and Support Service provides expertise in revealing and resolving such issues that are particular to any one study. The result is to create a robust environment for human subject research that not only meets the applicable rules and regulations, but promotes the conscientious conduct of these endeavors.



CCTS Research Concierge Services

Summary:

The Research Concierge provides complimentary consultative services to faculty and staff at The Ohio State University and Nationwide Children’s Hospital to navigate the complex research ecosystem and to connect with experts, resources and services at the CCTS and beyond. Since inception, the research concierge has assisted with hundreds of requests submitted by faculty, staff, students and the community.

Frontline Services
Triage and funneling of requests towards CCTS programs; often the first point of contact for the CCTS, referral to centers, programs, cores, shared services and other resources across the OSU and NCH campuses; creative problem solver and integration support to resolve research concerns.

Research Development
Identify and promote funding opportunities; match investigators with specialized faculty expertise for concept development and team science; communication liaison to address research needs rather than bounce from person to person looking for answers; assists with design, analysis, data collection and management plans, ethics considerations and regulatory plans; and to identify gaps and create new services to enhance research operations and efficiency.

Research Navigation
Identify research resources, services, programs or specialized equipment for investigators; navigation of complex research infrastructure; interpret and facilitate compliance with research and clinical policies and procedures; introduction to key leaders and staff.

Welcome Services
Formal presentations to groups and welcome consultations for new faculty; promotion and marketing of the CCTS programs internally and externally; champion translational science to larger research community, internal and external partners and public.



CCTS Trial Innovation Network

Summary:

A new national collaborative initiative aimed at improving investigator-initiated multicenter trial operations for Clinical and Translational Science Award (CTSA) consortium members across the US -including all investigators at OSU and NCH

The TIN provides services for all aspects of proposal development and execution including:
• Efficacy to Effectiveness (E2E) consultations on clinical trial design
• Development of robust recruitment plans and materials Serving as a Central IRB
• Serving as a clinical and/or data coordinating center



CCTS Voucher Program

Summary:

The OSU CCTS facilitates and supports the translation of scientific discoveries into innovations that improve health. To achieve this mission and advance translational research, the CCTS is awarding vouchers to provide funding support to investigators who require assistance from an eligible Ohio State University or Nationwide Children's Hospital core service to enable preliminary work and generate data for new or ongoing projects and/or to secure fee-based core services for expert consultation services with the ultimate goal of furthering clinical and translational research.

These awards are intended to be used on projects that are ready for services immediately (“just in time” data). The CCTS will award OSU and NCH investigators vouchers worth up to $3,000 in core services per investigator and per project. New to the program is the CCTS Collaboration voucher. The goal of this voucher is to increase collaboration across colleges and institutions. Projects with investigators from 2 or more colleges or institutions are eligible for up to $5,000 dollars in funding.



CCTS Workforce Development and Clinical Research Professional Education

Summary:

• Employing gamification for workforce development, including GCP training.
• Creating mini-modules for key clinical translational topics.
• Supporting and presenting at FDA Workshops.
• Developing a catalogue of publically available clinical research training at OSU and NCH.
• Connecting and collaborating with regional CRP workforce development initiatives.
• Connecting and collaborating with CTSA hubs through workforce development virtual
unmeetings.
• Exploring innovative methods for training delivery such as virtual reality.
• Exploring ePortfolios for CRP workforce development.
• Leading activities of the DIAMOND Portal and sharing OSU/NCH trainings in DIAMOND.
• Researching personalized pathways for CRPs.
• Researching the CRP role of nurses.
• Establishing a CRP Network for Listservs, Mentoring, and Leadership development.
• Developing and launching a Competency-based Curriculum for CRP Onboarding.
• Being a resource for collaborative CRP training.
• Supporting research in CRP workforce development.
• Supporting NLighten expansions and dissemination.
• Serving leadership roles in the ACTS/NCATS Task Force CRP Workforce Development.
• Studying assessments of CRP competence.



Campus Chemical Instrument Center (CCIC) Mass Spectrometry and Proteomics

Summary:

The mandate of the CCIC Mass Spectrometry and Proteomics (MSP) Facility is to provide state-of-the-art instrumentation and personnel expertise for a wide variety of research projects. Main areas of services we provide include i) proteomics, ii) metabolomics, and iii) general mass spec analyses for research groups. We also participate and provide support for grant applications and education. The Mass Spectrometry and Proteomics Facility at CCIC is an interdisciplinary unit, servicing faculty from the colleges of Biological Sciences, Education and Human Ecology, Engineering, Food, Agriculture & Environmental Sciences, Mathematical and Physical Sciences, Medicine, Optometry, Pharmacy, and Veterinary Medicine just to name a few. CCIC also serves scientists from other universities and industry within and outside of Ohio.

If you do not know what kind of service you need, please contact Dr Arpad Somogyi. Submit a Service Request Form through FOM – see instructions via link below. Please provide as much information as possible regarding the sample and desired analysis. Please note any special sample instructions or analysis instructions on the form. The more information we have, the better the results and the faster we can return data.

Bring sample(s) and the Service Request Form between 8AM & 5PM or mail to:

OSU Mass Spectrometry & Proteomics Facility
460 W 12th Ave, Rm 250 Biomedical Research Tower (BRT)
Columbus, OH 43210
Phone: 614-247-8789
Fax: 614-292-5955

Bring your Buck ID for access to our Facility in the Biomedical Research Tower.

Results are emailed and all data is electronic.
Samples are discarded after analysis, so please indicate if you would like to pick up any unused sample.



Campus Chemical Instrument Center Nuclear Magnetic Resonance (CCIC NMR)

Summary:

The CCIC NMR Facility is a state-of-the-art campus-wide core facility that currently houses nine high resolution Bruker NMR spectrometers (600 to 850 MHz) with a range capabilities: high-sensitivity cryoprobes for structural and dynamics studies of proteins, nuclei acids and their complexes, high-throughput sample changers (SampleCase and SampleJet) for metabolomics and drug screening for discovery, solid state probes for biomolecules and materials, micro-imaging and diffusion. The facility is located on both North Campus (CBEC building) and South Campus (Riffe building), which are within 15 minutes walking distance. This shared facility is one of the premier facilities of its kind in the US and is available to scientists within and outside of the OSU.

In addition, a cutting-edge ultrahigh field 1.2 GHz nuclear magnetic resonance (NMR) spectrometer has been funded by the National Science Foundation (NSF), which will be the centerpiece of the new National Gateway Ultrahigh Field NMR Center. Once commissioned, this next generation NMR instrument will be open to U.S. NMR researchers in the fields of biomolecular NMR of proteins and nucleic acids in solution and in the solid state, materials science, and metabolomics. The instrument will be run and maintained by CCIC NMR Facility staff.

About Facility Organization - the NMR facility operates under the administrative umbrella of the CCIC through the Office of Research (OR). It was founded in 1981 to provide state-of-the-art technology and services to all campus-wide researchers. The operation and service expenses are covered by user fees.

For citations please use this text: "Acknowledgement: This study made use of the Campus Chemical Instrument Center NMR facility at Ohio State University."



Campus Microscopy and Imaging Facility / Microscopy Shared Resource (CMIF/MSR)

Summary:

The Campus Microscopy and Imaging Facility (CMIF) serves University faculty staff and students as well as researchers outside Ohio State. The CMIF offers a full range of light, confocal, live-cell, super-resolution, and electron microscopes. Sample preparation equipment is available. Expert support and technical assistance enables users to collect and analyze high quality images.

This facility also functions as the Microscopy Shared Resource (MSR) which facilitates cancer research by providing an accessible centrally-organized resource with technical support for confocal, light, live cell microscopy, super-resolution microscopy and transmission electron microscopy. Highly qualified faculty and staff provide training and advice for sample preparation, processing fresh tissues, sectioning epoxy-embedded samples, basic microscopy, and advanced training in live animal multiphoton microscopy. The MSR, a part of the larger Campus Microscopy and Imaging Facility under the OSU Office of Research, is managed by the OSUCCC. The MSR is located within OSUCCC space in the Biomedical Research Tower. The ability to offer competitive pricing and exceptional service can be largely attributed to the generous support of outstanding institutional resources, including partnerships with the OSUCCC, the Office of Research, OSU Colleges and Institutes, and state and federal grants. The Microscopy Shared Resource (MSR) gives researchers access to state-of-the-art microscopes and to services ranging from standard light and electron microscopy to leading-edge, live-animal, multiphoton microscopy. MSR experts support high-level cancer research with the latest microscopy techniques.



Clinical Translational Science Shared Resource

Summary:

​The Clinical Translational Science Shared Resource (CTSSR) team works closely with clinical and translational scientists to develop a customizable portfolio of biomarker assays in order to provide innovative, correlative science studies associated with early-phase solid tumor oncology clinical trials.



Comparative Pathology & Digital Pathology Shared Resource

Summary:

The Comparative Pathology & Digital Imaging Shared Resource (CPDISR) provides expert, readily available and affordable experimental pathology support to investigators conducting research for understanding the development and treatment of cancer using preclinical animal models and/or human tissues procured for translational research. Comparative pathologists affiliated with the CPDISR are familiar with normal anatomy
and physiology, and pathology of many animal species, including the potential impact of confounding factors such as age- and strain-related background lesions, pathogens, and husbandry practices on study outcomes. Recognition of lesions and their interpretation in the context of individual investigations provides a critical component to research incorporating animal models.

The CPDISR provides support for preclinical efficacy and toxicity animal studies as well as translational studies that utilize human tissues procured for research, and can tailor its support to the needs of a client. Comprehensive services provided by the CPDISR include: animal blood and other biofluid analyses; macroscopic and microscopic examinations of full tissue sets from various species of laboratory animals; comprehensive histology services on paraffin-embedded and frozen tissues, encompassing special histochemical stains and immunohistochemical stains optimized for animal and human tissues; preparation of tissue microarrays and grids for transmission electron microscopy; slide digitization and quantitative image analysis; and hands-on training and consultation.

The CPDISR also provides a referral service with expertise in animal model development, experimental design, optimal sample collection, data analysis and interpretation, and grant/publication preparation.



Electronic Data Capture Core



Flow Cytometry Shared Resource

Summary:

The Flow Cytometry Shared Resource (FCSR) provides state-of-the-art flow cytometry analysis and sorting of cell populations using selected cellular markers. Flow cytometry is a critical technology for cancer research, and the ACSR is used extensively by all scientific programs in the OSUCCC – James and by the broader Ohio State research community.

Researchers can learn more about the use and application of flow cytometry in several ways, including scientific seminars, marketing at cancer-specific meetings, instrumentation overviews and application workshops. Additionally, the Mid-Ohio Cytometry Associates “users’ group” meets regularly to discuss relevant cytometry issues and to generate educational opportunities.



Genetically Engineered Mouse Modeling Core

Summary:

Modeling human disease in mouse provides a powerful tool for elucidating mechanisms and interrogating experimental therapeutics. The Genetically Engineered Mouse Modeling Core (GEMMC) is available to investigators who work or intend to work with mouse models of human disease.



Medicinal Chemistry Shared Resource

Summary:

The Medicinal Chemistry Shared Resource (MCSR) provides medicinal chemistry support to investigators at the OSUCCC – James and to other academic and commercial institutions. It integrates the expertise of multiple disciplines, including synthetic and process chemistry, instrumental analysis and molecular pharmacology.



National Gateway Ultrahigh Field NMR Center

Summary:

The mission of the new NSF-funded National Gateway Ultrahigh Field NMR Center is to promote and advance cutting-edge science using ultrahigh magnetic fields with focus on the areas of biomolecules and metabolomics by solution and solid-state NMR and materials science.

The centerpiece is a new 1.2 GHz NMR spectrometer with existing shared CCIC high-field NMR systems serving as staging instruments. Commissioning is expected over the next couple of years. Users from Academia, National Research Labs and Industry are supported by expert research scientists at the Center. The Center will also coordinate a diverse range of educational and outreach activities.



Nutrient and Phytochemical Analytics Shared Resource

Summary:

The Nutrient and Phytochemical Analytics Shared Resource (NPASR) provides investigators with expert bioanalytical method development and quantitative analysis. This resource supports development of methods and techniques to quantitatively determine nutrients and phytochemicals in foods. It also identifies these compounds and their metabolites in biological samples from human clinical trials and animal model investigations.

NPASR personnel are specialists in analytical chemistry who concentrate their expertise in examining the bioavailability, metabolism and physiological significance of carotenoids, isothiocyanates, isoflavones and other phytochemicals found in many foods.



Recruitment, Intervention and Survey Shared Resource

Summary:

The RISSR assists investigators with a comprehensive range of services related to research design and the selection and/or development of surveys, and studies measures to appropriately capture targeted constructs.



Small Animal Imaging Core

Summary:

The Small Animal Imaging Core (SAIC) is a small-animal imaging facility available to all investigators and other academic and commercial institutions.

The SAIC houses high-resolution imaging equipment and offers assistance from professionals who are experts in operating each imaging modality, small animal handling, and analytical software support for quantitative image analysis.



Small Animal Metabolic Core

Summary:

The goal of the Small Animal Metabolic Core is to provide expertise in metabolic studies including whole body metabolism, food intake and physical activity in small rodents.



Target Validation Shared Resource

Summary:

The Target Validation Shared Resource (TVSR) assists investigators in generating reliable proof-of-concept preclinical animal model data for grant applications, publications and IND applications for the FDA.

Preclinical mouse models of cancer have become indispensable for in vivo target validation studies, such as determining in vivo efficacy of therapeutics, unraveling in vivo off-target effects of therapeutics including unexpected negative side-effects in a whole organism, elucidating significance of biological pathways towards disease initiation/progression etc. The Target Validation Shared Resource assists investigators with these in vivo target validation studies.

The TVSR shared resource has expertise in establishing breeding programs for GEMM (genetically engineered mouse model) animals and immune-compromised mouse strains, developing xenograft/allograft mouse models of cancer, therapeutic compound administration and subsequent monitoring of the animals. It also provides consultation towards in vivo target validation study design.

The goal of TVSR is to assist investigators in generating reliable “proof-of-concept” preclinical animal (mouse) model data for grant applications, publications and filing of IND applications to FDA.



The CCC Proteomics Shared Resource (PSR)

Summary:

The Proteomics Shared Resource (PSR) provides OSUCCC – James members with complete proteomic support using a wide range of state-of-the-art mass spectrometers based analytical platforms. The PSR offers extensive technical expertise, leading mass spectrometers and supporting equipment to identify and characterize proteins, protein complex (via Native MS analysis), protein modifications, protein interactions and protein biomarkers as well as protein quantitation studies in cancer samples from various sources such as serum, urine, BAL fluid, saliva, frozen tissues, cell culture media, formalin-fixed tissues and cell lysates. The PSR also provides qualitative/statistical downstream analysis and visualization of data.



The Genome Editing Shared Resource (GEdSR)

Summary:

The Genome Editing Shared Resource (GEdSR) provides support to investigators in the design and establishment of gene-editing approaches for their experimental needs. By using CRISPR/Cas9-based technologies, the GEdSR helps research groups in the generation of knock-out and knock-in cellular systems. The GEdSR has 2 different sites of operation, located at the James Comprehensive Cancer Center and the Nationwide Children’s Hospital. The two sites have the capability to support both basic and translational gene-editing approaches.



The Microscopy Shared Resource (MSR)

Summary:

The Microscopy Shared Resource (MSR) provides timely and high-quality services to support OSUCCC investigators with instrumentation, technical advice and training on a variety of sophisticated microscopy approaches, including detection of viruses; examination of nanostructures for drug delivery with transmission electron microscopy; live cell imaging in response to different treatments; reconstruction of tumor models in three dimensions; and following dynamic events, such as the movement of immune cells in tumors of living animals using multiphoton microscopy. The MSR provides two critical shared resources, CEMAS and CMIF, for cancer investigators to translate fundamental studies of cancer biology into new treatments.



The OSU Pharmacogenomics Core Laboratory

Summary:

The Pharmacogenomics Core Lab in the OSU Center for Pharmacogenomics offers state of the art Next Generation Sequencing. We are an Ion Torrent Certified Service Provider for AmpliSeq transcriptomes and exomes as well as whole transcriptome analysis.



The Pharmacoanalytical Shared Resource

Summary:

The Pharmacoanalytic Shared Resource (PhASR) supports pre-clinical and clinical drug development at Ohio State by providing high quality and cost-effective bioanalytical method development, quantitative sample analysis, and pharmacokinetic / pharmacodynamic experimental design, data analysis and modeling.

Expertise among PhASR personnel includes quantitative pharmacology; bioanalytical methodology, design and conduct of pharmacokinetic/pharmacodynamic studies in animal disease models and in humans enrolled in clinical trials; data analysis and modeling of PK/PD data to inform drug development decisions. PhASR personnel are available for consultation on clinical or pre-clinical PK/PD experimental design and analysis.



University Laboratory Animal Resources

Summary:

University Laboratory Animal Resources (ULAR) facilitates the humane care and use of animals in biomedical research and teaching at Ohio State and also provides veterinary services. ULAR staff members oversee compliance with federal regulations and guidelines related to animal use and promote the responsible use of animals for the benefit of society.



Wysocki Research Group

Summary:

Under the direction of Vicki Wysocki, Professor of Chemistry and Biochemistry, Ohio Eminent Scholar, Director of the Campus Chemical Instrument Center, and Director of the NIH-funded Resource for Native Mass Spectrometry Guided Structural Biology, the Wysocki group includes graduate and undergraduate students, postdoctoral researchers and research staff,. Research in the Wysocki group is categorized into four broad areas: (1) development and implementation of surface-induced dissociation onto commercial time-of-flight, Orbitrap and FT-ICR instruments, (2) development and application of native mass spectrometry-guided structural biology approaches, (3) multi-omics approaches to biomarker discovery, disease diagnosis and prognosis using proteomics and metabolomics methods coupled with genomics and transcriptomics, and (4) determination of peptide and other fragment ion structures by IR action spectroscopy.



X-Ray Crystallography Facility

Summary:

Single crystal X-Ray diffraction is a leading technique for the determination of molecular and crystal structures and for obtaining the absolute configuration of molecules. This laboratory allows researchers to do small molecule single crystal structure determinations, where the metrical details of a molecule are ascertained (such as, bond lengths, bond angles, and conformation) along with the arrangement of the molecules within the solid state. Students with crystallographic experience can collect diffraction data and/or solve and refine their own structures. Otherwise, the complete structure analysis is done by the staff crystallographer



Found 42   core laboratories .

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